The defensive end suffered a moderate ankle sprain and will miss some practice time, a source informed of the situation told NFL Network Insider Ian Rapoport.
Wolfe also indicated on Twitter the injury is not serious.
Wolfe's ankle sprain comes on the heels of the Broncos losing defensive lineman Billy Winn for the season to a torn ACL suffered in Thursday's preseason game. The Broncos front-seven is also without Shaq Barrett (hip, NFI list), pass rusher Shane Ray (wrist) and nose tackle Kyle Peko (foot, physically unable to perform list).
Although it appears Wolfe will not miss any significant amount of time, Denver's defensive line still enters the season with plenty of questions. It's a group that struggled to stop the run last year. Injuries certainly wouldn't help reverse that trend.
Wolfe tallied 5.5 sacks in 14 games last season. His relentless pass rush was key for Broncos edge rushers getting shots at the quarterback.